The Ziarek lab in the department of Molecular and Cellular Biochemistry at Indiana University invites applications for a Postdoctoral Fellowship. http://www.ziareklab.com/
The long-term vision of our group is to decipher the molecular mechanisms of G protein-coupled receptor (GPCR) allostery for rational drug discovery. There is immense therapeutic potential in the ability to tune receptor signaling using partial agonists, biased agonists or allosteric modulators – and it remains virtually untapped. Our current understanding of biased agonism derives primarily from cell-based functional assays that are easily complicated by receptor expression levels, off-target effects and cell type. Integrating biophysical studies of purified protein with this cellular information will permit a complete molecular understanding. Our work aims to employ a combined biophysical, biochemical, cell-based, and computational approach to characterizing the role of both Monod-Wyman-Changeux (MWC) and dynamically-driven (DD) allosteric mechanisms in the context of GPCR and arrestin activation.
Beautiful Indiana University resides in Bloomington, Indiana – a small city nestled in unglaciated hills within driving distance of many large metropolitan areas. It offers a vibrant cultural life, superb music, and a diverse international campus community. Bloomington is bordered by Yellowwood State Forest, Brown Country State Park, and Hoosier National Forest – providing nearly unlimited recreational opportunities and is consistently ranked as one of the most livable towns in the country.
Best consideration date for applicants is September 7th, 2021, with a start date of early September.
Salary range starts at $47,000 annually and is commensurate with experience. The university offers excellent health insurance and benefits. Detailed benefit information can be found at http://hr.iu.edu/benefits/index.html#loaded .
Indiana University is an equal employment and affirmative action employer and a provider of ADA services. All qualified applicants will receive consideration for employment without regard to age, ethnicity, color, race, religion, sex, sexual orientation, gender identity or expression, genetic information, marital status, national origin, disability status or protected veteran status.
Interested candidates with a PhD in biochemistry, chemistry or a related field with relevant experience should submit their application at https://indiana.peopleadmin.com/postings/11224. A completed application includes a curriculum vitae, and a brief summary of past research experience. The applicant should also arrange for the submission of two recommendation letters, if selected for employment. One of which must be from their PhD advisor. Inquiries regarding this position can directed to Dr. Joshua Ziarek at email@example.com.
About Indiana University Purdue University Indianpolis - IUPUI
Founded in 1820, Indiana University is the state’s public university system, comprised of two core campuses—IU-Bloomington and IUPUI—and six regional campuses located throughout the state. Combined, the total student population is more than 114,000 undergraduate, graduate and professional school students. IU is one of the largest employers in the state, with over 20,000 faculty and staff. Indiana University is an equal employment and affirmative action employer and a provider of ADA services. Diversity and inclusion remains a core commitment to IU’s mission to cultivate an educational environment that supports equal access, participation and representation on all of its campuses and that provides educational and career opportunities for all.